Subclassification and Biochemical Analysis of Plant Papain-Like Cysteine Proteases Displays Subfamily-Specific Characteristics
نویسندگان
چکیده
منابع مشابه
Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.
Papain-like cysteine proteases (PLCPs) are a large class of proteolytic enzymes associated with development, immunity, and senescence. Although many properties have been described for individual proteases, the distribution of these characteristics has not been studied collectively. Here, we analyzed 723 plant PLCPs and classify them into nine subfamilies that are present throughout the plant ki...
متن کاملSubclassification and Biochemical Analysis 1 of Plant Papain - like Cysteine Proteases displays 2 Subfamily - specific Characteristics 3 4
Subfamily-specific Characteristics 3 4 Kerstin H. Richau*, Farnusch Kaschani*, Martijn Verdoes, Twinkal C. Pansuriya, 5 Sherry Niessen, Kurt Stüber, Tom Colby, Hermen S. Overkleeft, Matthew Bogyo 6 and Renier A. L. Van der Hoorn 7 8 * Equal contributions 9 10 1 The Plant Chemetics laboratory, Chemical Genomics Centre of the Max Planck 11 Society, Max Planck Institute for Plant Breeding Research...
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A series of 44 dipeptide nitriles with various amino acids at the P2 position and glycine nitrile at position P1 were prepared and evaluated as inhibitors of cysteine proteinases. With respect to the important contribution of the P2-S2 interaction to the formation of enzyme-inhibitor complexes, it was focused to introduce structural diversity into the P2 side chain. Nonproteinogenic amino acids...
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Transcriptomic and proteomic technologies are generating a wealth of data that are frequently used by scientists to predict the function of proteins based on their expression or presence. However, activity of many proteins, such as transcription factors, kinases, and proteases, depends on posttranslational modifications that frequently are not detected by these technologies. Therefore, to monit...
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Papain-like cysteine proteases (PLCPs) play crucial roles in plant-pathogen/pest interactions. During these parasitic interactions, PLCPs act on non-self substrates, provoking the selection of counteracting inhibitors and other means to evade proteolysis. We review examples of PLCPs acting on molecular battlefields in the extracellular space, plant cytoplasm and herbivore gut. Examples are maiz...
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ژورنال
عنوان ژورنال: Plant Physiology
سال: 2012
ISSN: 1532-2548
DOI: 10.1104/pp.112.194001